～2019年

【原著論文】
Wakabayashi K, Machitani M, Tachibana M, Sakurai F, Mizuguchi H.
A microRNA derived from adenovirus virus-associated RNAII promotes virus infection via post-transcriptional gene silencing.
J Virology, 2019; 93:e01265-18.

Inaba S, Hinohara A, Tachibana M, Tsujikawa K, Fukada S.
Muscle regeneration is disrupted by cancer cachexia without loss of muscle stem cell potential.
PLoS One, 2018; 13(10):e0205467.

Morikawa N*, Tachibana M*,#, Ago Y, Goda H, Sakurai F, Mizuguchi H#. (*contributed equally, #co-corresponding author)
LY341495, an mGluR2/3 antagonist, regulates the immunosuppressive function of myeloid-derived suppressor cells and inhibits melanoma tumor growth.
Biol Pharm Bull, 2018; 41(12):1866-1869.

Xie Z, Ago Y, Okada N, Tachibana M. (corresponding author)
Valproic acid attenuates immunosuppressive function of myeloid-derived suppressor cells.
J Pharmacol Sci, 2018; 137(4):359-365.

Tomita K, Sakurai F, Iizuka S, Hemmi M, Wakabayashi K, Machitani M, Tachibana M, Katayama K, Kamada H, Mizuguchi H.
Antibodies against adenovirus fiber and penton base proteins inhibit adenovirus vector-mediated transduction in the liver following systemic administration
Sci Rep., 2018; 8(1):12315.

Katayama Y, Tachibana M, Kurisu N, Oya Y, Terasawa Y, Goda H, Kobiyama K, Ishii KJ, Akira S, Mizuguchi H, Sakurai F.
Oncolytic Reovirus Inhibits Immunosuppressive Activity of Myeloid-Derived Suppressor Cells in a TLR3-Dependent Manner.
J Immunol. 2018; 200(8):2987-2999.

Hemmi M*, Tachibana M*,#, Fujimoto N, Shoji M, Sakurai F, Kobiyama K, Ishii KJ, Akira S, Mizuguchi H#. (*contributed equally, #co-corresponding author)
T Helper 17 Promotes Induction of Antigen-Specific Gut-Mucosal Cytotoxic T Lymphocytes following Adenovirus Vector Vaccination.
Front Immunol. 2017; 8:1456.

Machitani M, Sakurai F, Wakabayashi K, Nakatani K, Tachibana M, Kato N, Fujiwara T, Mizuguchi H.
Suppression of Oncolytic Adenovirus-Mediated Hepatotoxicity by Liver-Specific Inhibition of NF-κB.
Mol Ther Oncolytics. 2017; 7:76-85.

Sakurai F, Kunito T, Takayama K, Hashimoto R, Tachibana M, Sakamoto N, Wakita T, Mizuguchi H.
Hepatitis C virus-induced innate immune responses in human iPS cell-derived hepatocyte-like cells.
Virus Res. 2017; 242:7-15.

Hayatsu N*, Miyao T*, Tachibana M, Murakami R, Kimura A, Kato T, Kawakami E, Endo TA, Setoguchi R, Watarai H, Nishikawa T, Yasuda T, Yoshida H, Hori S. (*contributed equally)
Analyses of a Mutant Foxp3 Allele Reveal BATF as a Critical Transcription Factor in the Differentiation and Accumulation of Tissue Regulatory T Cells.
Immunity, 2017; 47(2):268-283.e9.

Hanawa M, Takayama K, Sakurai F, Tachibana M, Mizuguchi H.
Hepatocyte Nuclear Factor 4 Alpha Promotes Definitive Endoderm Differentiation From Human Induced Pluripotent Stem Cells.
Stem Cell Rev Rep., 2017; 13(4):542-551.

Sakai E, Miura Y, Suzuki-Kouyama E, Oka K, Tachibana M, Kawabata K, Sakurai F, Mizuguchi H.
A mammalian mirtron miR-1224 promotes tube-formation of human primary endothelial cells by targeting anti-angiogenic factor epsin2.
Sci Rep., 2017; 7(1):5541.

Iizuka S, Sakurai F, Tachibana M, Ohashi K, Mizuguchi H.
Neonatal Gene Therapy for Hemophilia B by a Novel Adenovirus Vector Showing Reduced Leaky Expression of Viral Genes.
Mol Ther Methods Clin Dev., 2017; 6:183-193.

Sakurai F, Inoue S, Kaminade T, Hotani T, Katayama Y, Hosoyamada E, Terasawa Y, Tachibana M, Mizuguchi H.
Cationic liposome-mediated delivery of reovirus enhances the tumor cell-killing efficiencies of reovirus in reovirus-resistant tumor cells.
Int J Pharm., 2017; 524(1-2):238-247.

Mitani S, Takayama K, Nagamoto Y, Imagawa K, Sakurai F, Tachibana M, Sumazaki R, Mizuguchi H.
Human ESC/iPSC-Derived Hepatocyte-like Cells Achieve Zone-Specific Hepatic Properties by Modulation of WNT Signaling.
Mol Ther. 2017; 25(6):1420-1433.

Machitani M, Sakurai F, Wakabayashi K, Nakatani K, Tachibana M, Mizuguchi H.
MicroRNA miR-27 Inhibits Adenovirus Infection by Suppressing the Expression of SNAP25 and TXN2.
J Virol. 2017; 91(12). pii: e00159-17.

Sakurai F, Mitani S, Yamamoto T, Takayama K, Tachibana M, Watashi K, Wakita T, Iijima S, Tanaka Y, Mizuguchi H.
Human induced-pluripotent stem cell-derived hepatocyte-like cells as an in vitro model of human hepatitis B virus infection.
Sci Rep. 2017; 7: 45698.

Takayama K, Igai K, Hagihara Y, Hashimoto R, Hanawa M, Sakuma T, Tachibana M, Sakurai F, Yamamoto T, Mizuguchi H.
Highly efficient biallelic genome editing of human ES/iPS cells using a CRISPR/Cas9 or TALEN system.
Nucleic Acids Res. 2017; 45(9):5198-5207.

Machitani M, Sakurai F, Wakabayashi K, Nakatani K, Takayama K, Tachibana M, Mizuguchi H.
Inhibition of CRISPR/Cas9-mediated genome engineering by a type I interferon-induced reduction in guide RNA expression.
Biol Pharm Bull, 2017; 40(3):272-277.

Machitani M, Sakurai F, Wakabayashi K, Takayama K, Tachibana M, Mizuguchi H.
Type I interferons impede short-hairpin RNA-mediated RNA interference via inhibition of dicer-mediated processing to small interfering RNA.
Mol. Ther. Nucleic Acids, 2017; 6:173-182.

Imagawa K, Takayama K, Isoyama S, Tanikawa K, Shinkai M, Harada K, Tachibana M, Sakurai F, Noguchi E, Hirata K, Kage M, Kawabata K, Sumazaki R, Mizuguchi H.
Generation of a bile salt export pump deficiency model using patient-specific induced pluripotent stem cell-derived hepatocyte-like cells.
Sci Rep. 2017; 7:41806.

Machitani M, Sakurai F, Wakabayashi K, Tachibana M, Fujiwara T, Mizuguchi H.
Enhanced oncolytic activities of the telomerase-specific replication-competent adenovirus expressing short-hairpin RNA against Dicer.
Mol Cancer Ther. 2017; 16(1):251-9.

Machitani M, Sakurai F, Wakabayashi K, Tomita K, Tachibana M, Mizuguchi H.
Dicer functions as an antiviral system against human adenoviruses via cleavage of adenovirus-encoded noncoding RNA.
Sci Rep. 2016; 6:27598.

Takayama K, Mitani S, Nagamoto Y, Sakurai F, Tachibana M, Taniguchi Y, Sekiguchi K, Mizuguchi H.
Laminin 411 and 511 promote the cholangiocyte differentiation of human induced pluripotent stem cells.
Biochem Biophys Res Commun. 2016; 474(1):91-6.

Nagamoto Y, Takayama K, Ohashi K, Okamoto R, Sakurai F, Tachibana M, Kawabata K, Mizuguchi H.
Transplantation of a human iPSC-derived hepatocyte sheet increases survival in mice with acute liver failure.
J Hepatol. 2016; 64(5):1068-75.

Negoro R, Takayama K, Nagamoto Y, Sakurai F, Tachibana M, Mizuguchi H.
Modeling of drug-mediated CYP3A4 induction by using human iPS cell-derived enterocyte-like cells.
Biochem Biophys Res Commun. 2016; 472(4):631-6.

Tsuzuki S*, Tachibana M*, Hemmi M, Yamaguchi T, Shoji M, Sakurai F, Kobiyama K, Kawabata K, Ishii KJ, Akira S, Mizuguchi H. (*contributed equally)
TANK-binding kinase 1-dependent or -independent signaling elicits the cell-type-specific innate immune responses induced by the adenovirus vector.
Int Immunol. 2016; 28(3):105-15.

Machitani M, Sakurai F, Wakabayashi K, Nakatani K, Shimizu K, Tachibana M, Mizuguchi H.
NF-κB promotes leaky expression of adenovirus genes in a replication-incompetent adenovirus vector.
Sci Rep. 2016; 6:19922.

Nakamori D, Takayama K, Nagamoto Y, Mitani S, Sakurai F, Tachibana M, Mizuguchi H.
Hepatic maturation of human iPS cell-derived hepatocyte-like cells by ATF5, c/EBPα, and PROX1 transduction.
Biochem Biophys Res Commun. 2016; 469(3):424-9.

Sakurai F, Narii N, Tomita K, Togo S, Takahashi K, Machitani M, Tachibana M, Ouchi M, Katagiri N, Urata Y, Fujiwara T, Mizuguchi H.
Efficient detection of human circulating tumor cells without significant production of false-positive cells by a novel conditionally replicating adenovirus.
Mol Ther Methods Clin Dev. 2016; 3:16001.

Ozawa T, Takayama K, Okamoto R, Negoro R, Sakurai F, Tachibana M, Kawabata K, Mizuguchi H.
Generation of enterocyte-like cells from human induced pluripotent stem cells for drug absorption and metabolism studies in human small intestine.
Sci Rep. 2015; 5: 16479.

Wakabayashi K, Machitani M, Shimizu K, Tachibana M, Sakurai F, Mizuguchi H.
Quantitative analysis of virus-associated RNAI expression following transduction with a replication-incompetent adenovirus vector in vitro and in vivo.
J. Mol. Genet. Med., 2015; 9:169.

Iizuka S, Sakurai F, Shimizu K, Ohashi K, Nakamura S, Tachibana M, Mizuguchi H.
Evaluation of Transduction Properties of an Adenovirus Vector in Neonatal Mice.
Biomed Res Int. 2015; 2015:685374.

Nagatake T, Fukuyama S, Sato S, Okura H, Tachibana M, Taniuchi I, Ito K, Shimojou M, Matsumoto N, Suzuki H, Kunisawa J, Kiyono H.
Central Role of Core Binding Factor β2 in Mucosa-Associated Lymphoid Tissue Organogenesis in Mouse.
PLoS One. 2015; 10(5):e0127460.

Hotani T, Tachibana M, Mizuguchi H, Sakurai F.
Reovirus double-stranded RNA genomes and polyI:C induce down-regulation of hypoxia-inducible factor 1α.
Biochem Biophys Res Commun. 2015; 460(4):1041-6.

Katayama Y, Terasawa Y, Tachibana M, Mizuguchi H, Sakurai F.
Proteolytic disassembly of viral outer capsid proteins is crucial for reovirus-mediated type-I interferon induction in both reovirus-susceptible and reovirus-refractory tumor cells.
Biomed Res Int. 2015; 2015:468457.

Terasawa Y, Hotani T, Katayama Y, Tachibana M, Mizuguchi H, Sakurai F.
Activity levels of cathepsins B and L in tumor cells are a biomarker for efficacy of reovirus-mediated tumor cell killing.
Cancer Gene Ther. 2015; 22(4):188-97.

Nagamoto Y, Takayama K, Tashiro K, Tateno C, Sakurai F, Tachibana M, Kawabata K, Ikeda K, Tanaka Y, Mizuguchi H.
Efficient engraftment of human iPS cell-derived hepatocyte-like cells in uPA/SCID mice by overexpression of FNK, a Bcl-xL mutant gene.
Cell Transplant., 2015;24(6):1127-38.

Takayama K, Morisaki Y, Kuno S, Nagamoto Y, Harada K, Furukawa N, Ohtaka M, Nishimura K, Imagawa K, Sakurai F, Tachibana M, Sumazaki R, Noguchi E, Nakanishi M, Hirata K, Kawabata K, Mizuguchi H.
Prediction of inter-individual differences in hepatic functions and drug sensitivity by using human iPS-derived hepatocytes.
Proc. Natl. Acad. Sci. USA, 2014; 111(47):16772-7.

Shimizu K, Sakurai F, Tomita K, Nagamoto Y, Nakamura S, Katayama K, Tachibana M, Kawabata K, Mizuguchi H.
Suppression of leaky expression of adenovirus genes by insertion of microRNA-targeted sequences in the replication-incompetent adenovirus vector genome.
Molecular Therapy-Methods and Clinical Development, 2014; 1, Article number: 14035

Hemmi M*, Tachibana M*, Tsuzuki S, Shoji M, Sakurai F, Kawabata K, Kobiyama K, Ishii KJ, Akira S, Mizuguchi H. (*contributed equally)
The early activation of CD8+ T cells is dependent on type I IFN signaling following intramuscular vaccination of adenovirus vector.
Biomed Res Int, 2014; 2014:158128.

Sakurai F, Nanjo Y, Okamoto S, Tachibana M, Mizuguchi H.
Upregulation of RECK gene expression by small double-stranded RNA targeting the promoter region.
Cancer Gene Ther., 2014; 21(4):164-70.

Watanabe H, Takayama K, Inamura M, Tachibana M, Mimura N, Katayama K, Tashiro K, Nagamoto Y, Sakurai F, Kawabata K, Furue MK, Mizuguchi H.
HHEX promotes hepatic-lineage specification through the negative regulation of Eomesodermin.
PLoS One, 2014; 9(3):e90791.

Kuno S, Sakurai F, Shimizu K, Matsumura N, Kim S, Watanabe H, Tashiro K, Tachibana M, Yokoi T, Mizuguchi H.
Development of mice exhibiting hepatic microsomal activity of human CYP3A4 comparable to that in human liver microsomes by intravenous administration of an adenovirus vector expressing human CYP3A4.
Drug Metab. Pharmacokinet., 2014; 29(4):296-304.

Machitani M, Sakurai F, Katayama K, Tachibana M, Suzuki T, Matsui H, Yamaguchi T, Mizuguchi H.
Improving adenovirus vector-mediated RNAi efficiency by lacking the expression of virus-associated RNAs.
Virus Res., 2013; 178(2):357-63.

Takayama K, Nagamoto Y, Mimura N, Tashiro K, Sakurai F, Tachibana M, Hayakawa T, Kawabata K, Mizuguchi H.
Long-term self-renewal of human ES/iPS-derived hepatoblast-like cells on human Laminin 111-coated dishes.
Stem Cell Rep., 2013; 1(4):322-35.

Matsui H, Sakurai F, Katayama K, Abe Y, Machitani M, Kurachi S, Tachibana M, Mizuguchi H.
A targeted adenovirus vector displaying a human fibronectin type III domain-based monobody in a fiber protein.
Biomaterials, 2013; 34(16):4191-201.

Takayama K, Kawabata K, Nagamoto Y, Kishimoto K, Tashiro K, Sakurai F, Tachibana M, Kanda K, Hayakawa T, Furue MK, Mizuguchi H.
3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing.
Biomaterials, 2013; 34(7):1781-9.

Shoji M, Katayama K, Tachibana M, Tomita K, Sakurai F, Kawabata K, Mizuguchi H.
Intramuscular DNA immunization with in vivo electroporation induces antigen-specific cellular and humoral immune responses in both systemic and gut-mucosal compartments.
Vaccine, 2012; 30(50):7278-85.

Shoji M, Tachibana M, Katayama K, Tomita K, Tsuzuki S, Sakurai F, Kawabata K, Ishii KJ, Akira S, Mizuguchi H.
Type-I IFN signaling is required for the induction of antigen-specific CD8(+) T cell responses by adenovirus vector vaccine in the gut-mucosa.
Biochem. Biophys. Res. Commun., 2012; 425(1):89-93.

Mukai K, Benbarak MJ, Tachibana M, Nishida K, Karasuyama H, Taniuchi I, Galli SJ.
Critical role of P1-Runx1 in mouse basophil development.
Blood, 2012; 120(1):76-85.

Nagamoto Y, Tashiro K, Takayama K, Ohashi K, Kawabata K, Sakurai F, Tachibana M, Hayakawa T, Furue MK, Mizuguchi H.
The promotion of hepatic maturation of human pluripotent stem cells in 3D co-culture using Type I collagen and Swiss 3T3 cell sheets.
Biomaterials, 2012; 33(18):4526-34.

Tomita K, Sakurai F, Tachibana M, Mizuguchi H.
Correlation between adenovirus-neutralizing antibody titer and adenovirus vector-mediated transduction efficiency following intratumoral injection.
Anticancer Res., 2012; 32(4):1145-52.

Matsui H, Sakurai F, Katayama K, Yamaguchi T, Okamoto S, Takahira K, Tachibana M, Nakagawa S, Mizuguchi H.
A hexon-specific PEGylated adenovirus vector utilizing blood coagulation factor X.
Biomaterials, 2012; 33(14):3743-55.

Katayama K, Furuki R, Yokoyama H, Kaneko M, Tachibana M, Yoshida I, Nagase H, Tanaka K, Sakurai F, Mizuguchi H, Nakagawa S, Nakanishi T.
Enhanced in vivo gene transfer into the placenta using RGD fiber-mutant adenovirus vector.
Biomaterials, 2011; 32(17):4185-93.

Tachibana M, Tenno M, Tezuka C, Sugiyama M, Yoshida H, Taniuchi I.
Runx1/Cbfβ2 complexes are required for lymphoid tissue inducer cell differentiation at two developmental stages.
J Immunol., 2011; 186(3):1450-7.

Tachibana M, Wada K, Katayama K, Kamisaki Y, Maeyama K, Kadowaki T, Blumberg RS, Nakajima A.
Activation of peroxisome proliferator-activated receptor  suppresses mast cell maturation involved in allergic diseases.
Allergy, 2008; 63(9):1136-47.

Tachibana M, Tezuka C, Muroi S, Nishimoto S, Katsumoto T, Nakajima A, Kitabayashi I, Taniuchi I.
Phosphorylation of Runx1 at Ser249, Ser266 and Ser276 is dispensable for bone marrow hematopoiesis and thymocyte differentiation.
Biochem Biophys Res Commun., 2008; 368(3):536-42.

Setoguchi R*, Tachibana M*, Naoe Y*, Muroi S, Akiyama K, Tezuka C, Okuda T, Taniuchi I. (*contributed equally)
Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development.
Science, 2008; 319(5864):822-5.

Takahashi H, Fujita K, Fujisawa T, Yonemitsu K, Tomimoto A, Ikeda I, Yoneda M, Masuda T, Schaefer K, Saubermann LJ, Shimamura T, Saitoh S, Tachibana M, Wada K, Nakagama H, Nakajima A.
Inhibition of peroxisome proliferator-activated receptor gamma activity in esophageal carcinoma cells results in a drastic decrease of invasive properties.
Cancer Sci., 2006; 97(9):854-60.

Wada K, Nakajima A, Katayama K, Kudo C, Shibuya A, Kubota N, Terauchi Y, Tachibana M, Miyoshi H, Kamisaki Y, Mayumi T, Kadowaki T, Blumberg RS.
Peroxisome proliferator-activated receptor gamma-mediated regulation of neural stem cell proliferation and differentiation.
J. Biol. Chem., 2006; 281(18):12673-81.

Katayama K, Wada K, Miyoshi H, Ohashi K, Tachibana M, Furuki R, Mizuguchi H, Hayakawa T, Nakajima A, Kadowaki T, Tsutsumi Y, Nakagawa S, Kamisaki Y, Mayumi T.
RNA interfering approach for clarifying the PPAR pathway using lentiviral vector expressing short hairpin RNA.
FEBS Lett., 2004; 560(1-3):178-82.
 
【総説論文】
立花雅史
HMGB1-TLR4シグナルによる骨髄由来免疫抑制細胞の機能制御
薬学雑誌、2018; 138(2):143-8.

清水かほり、櫻井文教、立花雅史、水口裕之
マイクロRNAを利用してウイルス遺伝子の非特異的な発現を抑制可能な新規アデノウイルスベクターの開発
薬学雑誌、2012; 132(12):1407-12.

Maeyama K, Emi M, Tachibana M.
Nuclear receptors as targets for drug development: peroxisome proliferator-activated receptor gamma in mast cells: its roles in proliferation and differentiation.
J. Pharmacol. Sci., 2005; 97(2):190-4.
 
【著書】
立花雅史，邊見昌久，水口裕之
第22章 粘膜免疫誘導型ワクチンとしてのアデノウイルスベクター
ドラッグデリバリーシステム-バイオ医薬品創成に向けた組織、細胞内、核内送達技術の開発-, シーエムシー出版, 2018: 175-82
​
【受賞】
​令和元年度　大阪大学賞（若手教員部門）　（立花）
平成29年度　第1回がんと代謝研究会　若手優秀賞　（立花）
平成29年度　第24回日本免疫毒性学会学術年会　年会賞　（立花）
平成28年度　日本薬学会近畿支部奨励賞　（立花）
​

2024

2021

2023

2020

2022

～2019